Missouri stormed out to a 21-0 first quarter lead on Saturday and cruised to a blowout 65-33 win against visiting Memphis in a non-conference game.

Drew Lock threw for 350 yards and four touchdowns in three quarters of work and Larry Rountree III rushed for 118 yards and three touchdowns on just nine carries as the Tigers of the SEC rolled up more than 600 yards against the Tigers of the American Athletic Conference.

Defense and special teams got things going for Missouri (4-3). A blocked punt on Memphis’ opening drive set Missouri up with a short field and Lock had a 19-yard keeper to set up a 2-yard plunge from Rountree for a 7-0 lead.

The SEC Tigers (4-3) doubled their lead on the next possession when Christian Holmes stepped in front of a Brady White pass and returned it 42 yards for the touchdown and a 14-0 lead.

After another Memphis three-and-out, Lock engineered a 5-play, 76-yard drive that ended with a 14-yard touchdown run from Damarea Crockett. Lock completed a 41-yard pass to Jalen Knox to get the drive going.

But Memphis (4-4) hung around early. A field goal from Riley Patterson made it 21-3 at the end of the first. And a couple of defensive stands resulted in back-to-back touchdown drives for the AAC Tigers. Patrick Taylor Jr. capped an 80-yard drive with a short touchdown run to make it 21-10 and White connected with Tony Pollard for a 30-yard touchdown to make it 21-17.

But then Lock got hot and Mizzou put up points as a rapid pace. Lock’s first touchdown pass was a 58-yard bomb to Albert Okwuegbunam to make the score 27-17. After an interception by Adam Sparks, Lock connected with Knox for a 44-yard touchdown and a 34-17 score.

Lock’s third touchdown pass of the quarter, a 47-yarder to Okwuegbunam, gave Mizzou a 48-20 lead into the half.

Okwuegbunam hauled in his third touchdown pass from Lock midway through the third quarter, a 23-yarder to make it 55-27. Rountree capped his strong day with a 59-yard touchdown run on a one-play drive that made the score 62-27 after three quarters. From there the coaches began subbing out the first-team offense, satisfied with one of the greatest offensive performances in school history.