The SEC has been one of the dominant leagues in college football throughout the last five seasons, but even the biggest, baddest conference in the land hasn’t been immune to the lowest of lows in organized sport — the upset. SEC teams have won national titles and BCS bowls, but they’ve also lost to teams like Jacksonville State and Louisiana-Monroe to remind us why they play the games.

It won’t be pleasant, but here are the SEC’s five worst upset losses of the last five years, dating back to the start of the 2010 season:

5. Mississippi State 10, No. 22 Florida 7 — 2010

Mississippi State head coach Dan Mullen made his first return trip to Gainesville since stepping down as Florida’s offensive coordinator two years earlier, and the Bulldogs new head man had a homecoming to remember against his former team.

The Gators had won 26 of 28 games in the two years leading up to their showdown with Mississippi State, including a national title and another BCS bowl win, while MSU had won just nine of 24 games in that same window. Nevertheless, the Bulldogs never backed down in a tough road environment against a ranked Florida team, leading to Mullen’s first signature win as a head coach.

Mississippi State jumped out to an early 10-0 lead in the first quarter thanks to a Sean Brauchle field goal and a six-yard touchdown scamper by quarterback Chris Relf. That would close Mississippi State’s scoring for the day, but those 10 points were all the Bulldogs would need.

The MSU defense forced a pair of turnovers and held an edge in time of possession, but the Bulldogs were also aided by a pair of missed field goals off the foot of Florida’s Chas Henry. Florida ate the last 7:50 off the clock in the fourth quarter to set up a potential game-tying field goal in the final seconds, but Henry missed the kick and Mississippi State held on to win.

Dan Mullen didn’t win another game against a ranked team until 2014, but for one magical day in 2010 he put forth the coaching performance of his life in one of the best upsets of that SEC season.

4. Jacksonville State 49, Ole Miss 48, 2OT — 2010

There was plenty of buzz surrounding the Ole Miss football program to start the 2010 season upon the arrival of Oregon transfer Jeremiah Masoli. Many expected Masoli to be the Rebels’ best quarterback since the days of Eli Manning during his one and only year in Oxford, but the Rebs’ season ended as quickly as it began with a Week 1 loss to Jacksonville State of the Division I-AA ranks.

Ole Miss appeared to have the game in hand with a comfortable 31-10 lead at halftime and a 31-13 lead through three quarters, but three fourth quarter touchdowns from the JSU offense pulled the two teams even at 34-all, forcing overtime in Vaught-Hemingway Stadium.

The two teams traded touchdowns in the first overtime and did so again in the second overtime. Jacksonville State possessed the ball second in the second overtime, and upon scoring what appeared to be the game-tying touchdown to force triple overtime the Gamecocks instead went for two and the win right then and there.

JSU quarterback Coty Blanchard found Calvin Middleton in the end zone for the game-winning conversion, handing Jacksonville State a stunning upset to spoil a promising season in Oxford.

Ole Miss committed three turnovers (JSU committed zero) in what remains its worst loss of the last five seasons. The Rebels closed the 2010 season with a 4-8 record, missing a bowl game altogether in Masoli’s only year in Oxford.

3. Louisiana-Monroe 34, No. 8 Arkansas 31, OT — 2012

The Hogs led 28-7 in the third quarter but allowed ULM to score three unanswered touchdowns to tie the game with less than a minute remaining in regulation.  Warharks quarterback Kolton Browning found Brent Leonard for a 23-yard touchdown on fourth and 10, leaving fans of both teams stunned for different reasons.

Arkansas took over on offense in the first half of overtime and capped its possession with a Zach Hocker field goal to retake the lead. The Hogs held ULM for three plays to start the second half of the overtime session, and facing a fourth and 1 from the 16 ULM elected to leave its offense on the field rather than attempt a game-tying field goal.

Browning kept the ball himself, and not only did he pick up the first down, he ran all the way to the end zone for the game-winning score. The Warhawks out-scored Arkansas 27-3 to close the game. The Razorbacks finished the year with a 4-8 record.

2. Indiana 31, No. 18 Missouri 27 — 2014

Missouri’s second straight SEC East title this season will forever be overshadowed by an embarrassing home loss to Indiana, which finished the season 4-8 overall and 1-7 in the Big Ten.

The Tigers fell behind in the first quarter following a Tevin Coleman touchdown run to put the Hoosiers ahead by seven. The two teams went back and forth for most of the first half, and Mizzou led for just 2:42 before an Indiana field goal tied the game at 17-all as time expired in the half.

The Hoosiers took another seven-point lead in the second half on a 33-yard touchdown pass from Nate Sufield to J-Shun Harris in the third quarter, but the Tigers scored 10 unanswered points early in the fourth quarter to claim a three-point lead with just 2:20 remaining on the clock.

The Tigers appeared to have avoided catastrophe by reclaiming a late lead, but Indiana never lost its composure. Sudfield led the offense on a six-play, 75-yard drive culminating with a D’Angelo Roberts touchdown run to give the Hoosiers a 31-27 lead. Mizzou had 22 seconds to answer, needing a touchdown to overcome the four-point deficit.

The Tigers were able to move across midfield and set up a Hail Mary try from the IU 48 yard line, but the pass fell incomplete and the Hoosiers closed out their incredible upset in Columbia. Mizzou would only lose one other time all season, but the loss to Indiana hurt the Tigers in the national polls, as their division title never equated to a ranking higher than No. 16 following the loss to IU.

1. Georgia Southern 26, Florida 20 — 2013

Florida’s loss to Georgia Southern was the perfect storm of What the heck am I watching?!?! in the second-to-last week of the 2013 season.

The Gators spent much of the year floundering under coach Will Muschamp, and they’d need to win both of their final two games against Georgia Southern and Florida State to reach bowl eligibility, something often taken for granted in Gainesville. Most Gators fans considered FSU to be the most daunting hurdle in the final stretch of the year, but GSU proved it was a force to reckoned with as well.

Like many of the other upsets on this list, the favored team, in this case Florida, took an early lead. The Gators led 10-0 early in the second quarter of play, and even after a GSU touchdown late in the half cut the lead to 10-7 the Gators still appeared in control despite a tight score.

But the Eagles picked up where they left off in the first half, scoring back to back touchdowns to open the second half and take a 20-10 lead in the Swamp. With Gators fans sweating an upset, their offense promptly responded with 10 unanswered points to tie the score once again at 20-apiece.

Georgia Southern reclaimed possession late in the fourth quarter and had one final chance to drive for the game-winning score. And that’s exactly what the Eagles did.

GSU drove 75 yards on just five plays, culminating with a Jerick McKinnon touchdown run to give the Eagles a 26-20 lead with fewer than three minutes remaining. Florida went 47 yards in 10 plays in its attempt to win the game on its final drive, but the Gators ran out of time at the GSU 17 yard line, losing the game to clinch a losing record for the first time since 1979.

The game will always be remembered for a play in which two Florida players were caught blocking one another, a microcosm of the disastrous chaos that ensured in Gainesville that year. It’s also worth noting Georgia Southern won the game without completing a pass — quarterback Kevin Ellison was 0-3 passing, but the Eagles ran the ball for 429 yards at close to eight yards per carry.