Missouri’s starting left guard Anthony Gatti went down clutching his right knee in the first quarter, while Indiana’s star running back Tevin Coleman also got carted to the locker room.

Redshirt junior Brad McNulty replaced Gatti, a 6-foot-6, 315-pound redshirt senior. Though Missouri hasn’t given any official update, the injury to Gatti’s knee appears serious. Cameras showed Gatti visibly upset on the sideline in the second quarter.

Meanwhile, Coleman exited the game in the first quarter after 10 touches for 32 yards and a touchdown. TV cameras caught the training staff working furiously on Coleman as other personnel blocked the view with towels.

With Missouri defensive end Markus Golden out due to a hamstring injury and Coleman also out, Indiana has thrown the ball with success in the first half.

The Tigers haven’t blocked well in the run game against Indiana, and replacing a starting left guard mid-game isn’t helping.