Betting Stuff: Best bets for Week 12 of the 2025 college football season

Week 12 schedule, odds

SDS is your one-stop shop this season, with live, up-to-date college football odds. You can find point spreads, game totals, and money line odds for every Week 12 game below.

Bet Oregon-Minnesota total under 44.5 points (-112 via DraftKings)

In what was Oregon head coach Dan Lanning’s only media availability of the week, he was less than forthcoming offering updates on a lengthy list of injured Ducks. Oregon needed a last-minute field goal to beat Iowa on the road in Week 11, and it came out of that game beaten to a pulp despite just having the prior week off.

Wideout Dakorien Moore and tight end Kenyon Sadiq did not play against Iowa. Slot receiver Gary Bryant Jr. left the game in the first quarter and didn’t return. The Ducks were down to 4 scholarship receivers against the Hawkeyes. They were also missing starting right tackle Alex Harkey, among a few others.

Now, Oregon has a short week to prepare for a Minnesota team that will have a major rest advantage. Given the situational spot and Oregon’s host of injuries on offense, does Oregon have its usual juice? Even if the Ducks rally, they haven’t had much “juice” lately anyway.

Oregon has been held to 21 points or less in regulation in 4 of its last 5 games. Minnesota also stinks. It has been demolished in each of its last 2 road games by a combined score of 83-6. On a Friday night, I think Oregon tries to shorten the game and make quick work of a Minnesota team that shouldn’t threaten much. With several playmakers dealing with injuries, it’s also worth considering that another week of rest could do Oregon well ahead of a Nov. 22 matchup with USC.

Bet Alabama -6 vs. Oklahoma (-110 via BetMGM)

Oklahoma feels like a popular pick this week, 2 weeks removed from knocking off Tennessee in Knoxville. But I’m still not sold on the Sooners. R Mason Thomas returned a fumble 71 yards for a defensive score and Oklahoma got 6 points off a pair of Joey Aguilar interceptions in the win. The Sooners were out-gained on a per-play basis and gave up nearly 400 passing yards.

Alabama’s defense is significantly better than Tennessee’s. The Vols give up 2.6 points per possession this year. Alabama gives up 1.7. Tennessee ranks 118th nationally in adjusted EPA per play allowed. Alabama ranks 26th. At this point, the safer assumption is that OU’s rushing success against Tennessee had more to do with the Vols than it did with the Sooners. And quarterback John Mateer still looked off in the throw game, finishing with an interception, no touchdowns, and a 5.5 yards-per-play clip.

Ty Simpson should have the same kind of success against the OU secondary that Aguilar did. And he might not make the same back-breaking mistakes. Absent those gifts, I don’t trust the Oklahoma offense to pull off 2 road upsets in consecutive games.

Bet Utah -8 at Baylor (-110 via Fanatics)

Utah ranks eighth nationally in net success rate, per Game on Paper. Baylor ranks 69th. We know that defense travels, and Utah has prevented more than three-quarters of all opponent drives from producing points this season, per ESPN. Baylor has been loose with the ball all year (17 giveaways, tied for 122nd nationally) and can’t defend the run. Utah has been demolishing teams all season long and I see no reason why that shouldn’t continue in Waco. If Auburn can win by double-digits there, Utah sure can.

Derek Peterson

Saturday Down South • November 11, 2025 at 3:55pm