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Missouri Tigers Odds, Spreads, Over Unders for 2025

Last Updated: Jul 22, 2025 · 2:50 PM EDT

Odds for Mizzou Football have already opened.
Mizzou’s projected win total is 7.5, according to several sportsbooks.
See the latest Mizzou football odds and more below.

Mizzou Football is rising under head coach Eli Drinkwitz.

The Tigers posted back-to-back 10-win seasons in 2023 and 2024 while becoming a fixture in the AP Top 25 poll.

In 2025, expectations are higher than ever: Mizzou appeared in the top 10 of several way-too-early rankings and has been discussed as a dark-horse Playoff contender. No wonder Mizzou football odds are attracting attention.

We’ll explore every aspect of Missouri football odds below.

Missouri Tigers Over/Unders

Most sportsbooks have set Mizzou’s win total at 7.5 for the 2025 regular season.

At bet365, the odds are +135 for over 7.5 wins, and the odds are -165 for under 7.5 wins.

With those odds, if you bet $10 on the over and Mizzou wins 8 or more games, you would win $23.50. If you bet $10 on the under and the Tigers won 7 or less games, you would win $16.10.

If you are in a legal betting state, you can take advantages of some of bet365’s promos.

Missouri Tigers Odds vs Central Arkansas (Week 1)

Missouri opens the 2025 college football season on Thursday Aug. 28 vs. Central Arkansas.

Central Arkansas is an FCS program that finished 6-6 in 2024. The Bears didn’t play a power conference team in 2024, but in 2023, they fought Oklahoma State before losing 27-13.

Once oddsmakers set the Mizzou football line, these odds will update automatically every time they change.

Missouri Tigers vs. Kansas Odds (Week 2)

Mizzou vs. Kansas is one of college football’s best rivalries. After a relatively brief hiatus, the border rivals will renew the rivalry in 2025. It’s their first meeting since 2011, when Mizzou left the Big 12 for the SEC after the season.

After oddsmakers set the Mizzou football line, the betting line will update automatically every time they change.

Missouri Tigers vs Louisiana Odds (Week 3)

Mizzou has never played Louisiana, but the Ragin’ Cajuns are no stranger to facing SEC teams. Of course, Louisiana has yet to beat an SEC team. Entering 2025, the Ragin’ Cajuns are 0-46 vs. the SEC. Oddsmakers like this Louisiana team, however. Sportbooks like bet365 have set the Ragin Cajuns’ over/under win total at 7.5.

These Mizzou football odds will update automatically every time the Missouri spread changes.

Missouri Tigers vs South Carolina Odds (Week 4)

The Battle of Columbia returns to The Rock as Mizzou hosts South Carolina on Sept. 20, 2025.

Mizzou vs. South Carolina is a new rivalry. Mizzou leads the all-time series, but the Gamecocks won in 2024 and boast a Heisman Trophy contender in QB LaNorris Sellers.

These odds will update automatically every time the Missouri spread changes.

Missouri Tigers vs UMass (Week 5)

Mizzou wraps up the nonconference portion of its 2025 football schedule against UMass, which went 2-10 as an independent in 2024. UMass has joined the Mid-American Conference for 2025, but most sportsbooks have set the Minutemen’s over/under win total at 3.5.

Expect Mizzou to be a heavy betting favorite again. These odds will update automatically every time the Missouri spread changes.

Missouri Tigers vs Alabama Odds (Week 7)

The Tigers have a bye week to prepare for their SEC opener on Oct. 11, 2025 vs. Alabama.

The Crimson Tide shut out Mizzou in 2024, winning 34-0 in Tuscaloosa.

Mizzou likely will be an underdog for the first time in 2025, even though the game is at Faurot Field.

This Mizzou football spread will update automatically every time the Missouri line changes.

Missouri Tigers vs Auburn Odds (Week 8)

After opening the season with 6 home games at Faurot Field, Mizzou finally hits the road in Week 8.

Mizzou travels to face Auburn, which the Tigers beat 21-17 in 2024. There’s not much history here. Mizzou has only played Auburn 5 times.

It will be interesting to follow the Missouri betting line on this game. These odds will update automatically every time the Mizzou football spread changes.

Missouri Tigers vs Vanderbilt Odds (Week 9)

Mizzou hits the road for the second consecutive week, this time traveling to Nashville to face QB Diego Pavia and the Vanderbilt Commodores.

Under Eli Drinkwitz, Mizzou has defeated Vandy 5 consecutive times, including last season’s dramatic 30-27 victory in double overtime at The Rock.

Fans and bettors can track the odds for the Mizzou-Vandy football game.

Missouri Tigers vs Texas A&M Odds (Week 11)

Mizzou has a bye week in Week 10, so it will get an extra week to prepare for the Aggies.

As an added bonus, Mizzou is returning home to Faurot Field for the Nov. 8, 2025 kickoff vs. the Aggies.

Be sure to track these Mizzou football odds, which will update automatically every time the Mizzou betting line moves.

Missouri Tigers vs Mississippi State Odds (Week 12)

SEC media members predicted Mississippi State would finish last in the SEC in 2025.

If that prediction in trending toward becoming correct, expect the Tigers to be a home favorite vs. the Bulldogs on Nov. 15, 2025.

These Mizzou football odds will update automatically every time the Missouri spread changes.

Missouri Tigers vs Oklahoma Odds (Week 13)

Missouri vs. Oklahoma is a longtime rivalry that is quickly closing in on the 100th meeting.

Oklahoma has dominated the all-time series, but Mizzou won the first head-to-head encounter as SEC teams. The Tigers handled the Sooners 30-23 in 2024 at Faurot Field.

On Nov. 22, 2025, the Tigers head to Oklahoma, which has high hopes under new starting QB John Mateer.

The Mizzou betting line likely will shift numerous times before kickoff. You can track the live updates for the Mizzou spread here.

Missouri Tigers vs Arkansas Odds (Week 14)

Mizzou closes the 2025 regular season with a road trip to Arkansas on Nov. 29.

Sure, Missouri vs. Arkansas is a relatively new rivalry, one all but forced on the Tigers when they joined the SEC in 2012. No matter. The Tigers have owned it.

Mizzou enters the game at Arkansas with a 3-game winning streak vs. the Razorbacks.

As soon as this Mizzou betting spread is established, you can track how the odds change here.

Missouri Tigers Odds to Make Playoff

Will Mizzou make the College Football Playoff in 2025-26? This searchable chart allows you to track Mizzou football odds throughout the season. Just use the dropdown to select “To Reach The Playoffs” and begin searching for Mizzou and other teams of interest. These odds will update automatically. You can find Mizzou’s odds to reach the Playoff, plus other teams.

Missouri Tigers Odds to Win SEC Championship

Bet365 is one of many sportsbooks offering odds to win the SEC Championship.

As of July 18, Mizzou’s odds to win the SEC Championship are +5000.

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Missouri Tigers Odds to Win the National Championship

In 2025-26, 12 teams will make the College Football Playoff. One team will win the national championship.

DraftKings Sportsbook currently lists Mizzou’s odds to win the national championship at +15000.

Reigning national champion Ohio State has the top odds at +500.

Missouri Sportsbook Promos

Missouri sports betting is expected to be live in December of 2025. Saturday Down South has you covered with a thorough look at the best Missouri Sportsbook Promos.

Here you can find some of the best sportsbook promos:

Chris Wright

Managing Editor

A 30-time APSE award-winning editor with previous stints at the Miami Herald, The Indianapolis Star and News & Observer, Executive Editor Chris Wright oversees editorial operations for Saturday Down South.