It’s time for Week 10 of the 2025 NFL season, which means 3 more bold predictions to consider for this NFL Sunday.
Last week, we went 1-2 with these plus-money bets. The Denver Broncos won outright against Houston as +110 underdog but that was our only winner of the weekend.
We’ll strive for a better Week 10.
NFL Week 10 bold predictions
Here are 3 plus-money bets to consider for this week:
Giants over Bears
I like the Giants to win outright against Chicago this weekend. The Bears have consistently found ways to lose games this season — and they were on track to do so again last weekend before a miracle long touchdown pass to Colston Loveland in the game’s final minute. Caleb Williams looked excellent last week, but I expect New York’s defense to offer a little more resistance than Cincinnati’s did. On the other side of the ball, the Giants offense ranks top-5 in the NFL in EPA-per-play since Week 6.
Pick: Giants money line +190 (via Fanatics)
Amon-Ra St. Brown 100+ receiving yards
The Commanders have one of the worst secondaries in the NFL and it’s been getting worse in recent weeks. Since the start of Week 7, they rank dead last in the NFL in EPA-per-drop-back allowed. Washington also has one of the most-targeted slot cornerbacks in the NFL this season in Mike Sainristil. Per PFF, he’s seen 42 slot targets this season and has allowed 32 catches for 362 yards on those attempts. His 1.78 yards per snap allowed out of the slot ranks next-to-last in the NFL among slot corners with at least 100 coverage snaps this season. Enter one of the NFL’s most prolific wide receivers: Amon-Ra St. Brown. Detroit gets creative with where he lines up, but he’s in the slot about half the time. I like his price to go over the century mark for the third time this season against a Washington defense that has neither the talent nor the motivation to stop him.
Pick: Amon-Ra St. Brown 100+ receiving yards (+145 on BetMGM)
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Quinshon Judkins to score twice
The Jets are near the very bottom of the NFL when it comes to rushing defense. This looks like a great matchup for running back Quinshon Judkins, who has already amassed 20 red zone rush attempts so far this season. He’s turned 4 of those into touchdowns. The Browns aren’t great on offense, but they’ll be getting to face a Jets defense that was just gutted at the trade deadline. Among the players New York moved was defensive tackle Quinnen Williams, who is among the best run defenders in the NFL.
Pick: Quinshon Judkins 2+ TDs (+370 on DraftKings)
Spenser is a news editor for Saturday Down South and covers college football across all Saturday Football brands.
